Research in the Yates lab is focused on the development and application of mass spectrometry-based proteomics techniques to a wide range of biological questions. Our lab has been instrumental in the evolution of the field to its current status, having pioneered many of the landmark advances that form the basis for prevailing proteomics practices, including shotgun proteomics (McCormack, A. L.; Schieltz, D. M.; Goode, B.; Yang, S.; Barnes, G.; Drubin, D.; Yates, J. R., III. Anal. Chem. 1997, 69, 767−776), database searching (SEQUEST, Eng, J. K.; McCormack, A. L.; Yates, J. R., III. J. Am. Soc. Mass Spectrom. 1994, 5, 976−989), and Multidimensional Protein Identification Technology (MudPIT, Washburn, M. P.; Wolters, D.; Yates, J. R., III. Nat. Biotechnol. 2001, 19, 242−247). We continue the drive to increase the scope, sensitivity and throughput of proteomics technologies and their application to biological questions.
Our research encompasses the areas of bioinformatics and software development, methods development and biological applications. The integration of all the elements in the proteomics pipeline within one lab facilitates advances in all of them.
The Yates lab has published more than 700 peer reviewed papers. Recent highlights include comprehensive proteomics studies revealing molecular mechanisms implicated in Cystic Fibrosis as well as identification of proteins capable of restoring function to mutated proteins in the disease, and investigations into affective disorders of the brain, including schizophrenia and depression.